Research &
Development
Rational Drug Design
The main aim is to develop drugs through
rational drug design, build software,
databases and methodologies in the field of
Proteomics and drug design. The main focus
areas are Proteins in Tissue factor Pathway,
Ligand design for G-Coupled receptors and
HIV Integrase. & Identification of New Drug
Targets & Development of Potential Drug for
tuberculosis - An Innovative Approach -
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Mining of novel diagnostic markers and drug
targets from Metabolic pathways:
The main objective of this project is to
develop software tools for
simulating/engineering the Metabolic
Pathways of various diseases by using
available full genome data, 3D- structural
data of the proteins, metabolites, Enzymes
etc to assign putative functions to genes by
using various properties other than sequence
similarity and the knowledge of existing
generalized pathways will be superimposed to
describe the pathways in a given organism.
By doing so we are trying to establish
potential diagnostic markers for various
diseases and identify potential drug
targets. The identified putative molecule
would be further characterized in the
wet-lab to establish its function.
C. Development of Protein Ligand database
for Autoimmune diseases:
This project aims at creating a database
which provides the complete information of
Autoimmune Disease and their respective
ligands. This database provides details
about the autoimmune diseases. Involves the
identification of the target regions.
Involves the prediction of the structure of
the receptors and Identification of the
target drugs
D. Generation of Transgenic Cow resistant to
Foot and Mouth disease:
The objective of the project is to develop a
Transgenic cow, resistant to Foot and Mouth
disease. Transgenic animals resistant to
Foot and Mouth Disease Virus (FMDV) would
not only prevent the virus from infecting
the animal but also give rise to FMD
resistant offspring from the transfected
animals. Being an economical important
disease the eradication of this disease will
help the livestock owners to upgrade their
livestock resulting in increased milk
production, meat production and quality
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